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Editors
Scientific Reports is run by a team of experienced editors who are experts in their fields. From our Editorial Board Members and Senior Editorial Board to our in-house Editors, we work togetherResearch integrity issue to ensure that your research is expertly handled and that we consider it to be technically sound, scientifically valid, and ultimately suitable for publication.
Interview with Rafal Marszalek, Chief Editor of Scientific Reports
In-house Editors
Chief Editor: Rafal Marszalek, PhD; Springer Nature, UK
Rafal's background is analytical and biological chemistry. He did his PhD and postdoctoral research in single-cell proteomics at Imperial College London, UK. He was an editor at Genome Biology before joining Scientific Reports in August 2016.
ORCID 0000-0003-0316-1363
Deputy Editor: Elizabeth Mann, PhD; Springer natur, UK
Elizabeth has a background in pharmacology and completed her PhD in neuropharmacology at King's Col
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2001 to 2015
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Redox-Dependent Impairment of Vascular Function in Sickle Cell Disease
Abstract
The vascular pathophysiology of sickle cell disease (SCD) is influenced by many factors including adhesiveness of red and white blood cells to endothelium, increased coagulation and homeostatic perturbation. The vascular endothelium is central to disease pathogenesis because it displays adhesion molecules for blood cells, balances procoagulant and anticoagulant properties of the vessel wall and regulates vascular homeostasis by synthesizing vasoconstricting and vasodilating substances. Occurrence of intermittent vascular occlusion in SCD leads to reperfusion injury associated with granulocyte accumulation and enhanced production of reactive oxygen species. The participation of nitric oxide (NO) in oxidative reactions causes a reduction in NO bioavailability and contributes to vascular dysfunction in SCD. Therapeutic strategies designed to counteract endothelial, inflammatory and oxidative abnormalities